Designer 4.10 might not start on MacOS, I got two errors during startup:
First this:

Follow this TID: https://support.microfocus.com/kb/doc.php?id=7024282
Then it will complain that it can’t find "../../../jre/lib/server/libjvm.dylib"
There is a bug in /Applications/Designer/Designer.app/Content/MacOS/Designer.ini.
This is wrong: ../../../jre/lib/server/libjvm.dylib
It should be: ../../../jre/jre/lib/server/libjvm.dylib